Thursday, January 13, 2005

Nature chimes in: will we dodge another bullet?

In a strongly worded Editorial entitled "Dangerous state of denial" the prestigious scientific journal Nature expresses the concern, also voiced here, about a seeming lack of urgency regarding a potential pandemic from avian influenza A(H5N1):
Despite the warning shots of SARS and last year's Asian outbreak of avian flu, governments are still not doing enough to monitor and prepare for the next viral pandemic. This inaction is scandalous. . . [emphasis in original]

Since H5N1 starting spreading through Asian poultry flocks in 2003, the World Health Organization (WHO) has been sounding the pandemic alarm. Two main actions are required. First, surveillance for human and animal flu viruses in affected countries needs to be stepped up, to provide an early warning of the emergence of a possible pandemic strain. Second, nations around the world must develop plans to protect their populations should this occur. This will require stringent quarantine procedures, plus the rapid deployment of vaccines and antiviral drugs.

Surveillance in Asia leaves much to be desired. In Vietnam, where at least 22 people have already died, officials lack the resources to conduct the extensive serological studies that are needed to investigate the full extent of human infection (see page 102). Neighbouring Laos and Cambodia, meanwhile, have virtually no monitoring capacity. The WHO has appointed an official in Geneva to coordinate Asian research efforts, and has enlisted the help of the US National Institute of Allergy and Infectious Diseases to establish a regional clinical research network. But much more needs to be done.

On the veterinary side, the picture is even bleaker. Rich governments are disinclined to build up poor countries' ability to keep track of animal viruses, seeing this as economic assistance rather than humanitarian aid. The experience of smallholders like Luat shows that surveillance for such viruses has vast local economic significance. But rich countries must abandon their mindset of protectionism and realize that establishing global surveillance will ultimately help protect the health and economic productivity of their own citizens.

The lack of assistance with surveillance is hardly surprising, however, when you consider that few rich nations have made any effort to stockpile Tamiflu, the one drug that can combat a flu virus as pathogenic as H5N1, nor to ramp up capacity to produce large quantities of a new vaccine should a pandemic strain emerge. On 8 December, the WHO summarized the situation: "While it is impossible to accurately forecast the magnitude of the next pandemic, we do know that much of the world is unprepared for a pandemic of any size."

The world dodged a bullet in 2003, when a newly emerging coronavirus sparked an outbreak of severe acute respiratory syndrome, or SARS. We may yet avoid H5N1 flu, but sooner or later we will face a new global viral pandemic, probably triggered by a chance encounter between a mammalian flu virus and an avian one, such as H5N1. When that happens, and the corpses start piling up, world leaders will be asked some searching questions about the steps they took to avoid such a calamity and to prepare for the worst.